Avatrombopag Impurity 138 CAS 570403-14-4(free base)
| CAS No. | 570403-14-4(free base) |
| Molecular Formula | C32H40Cl2N6O3S2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Avatrombopag Impurity 138 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Avatrombopag Impurity 138 (CAS 570403-14-4(free base), C32H40Cl2N6O3S2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Avatrombopag Impurity 138 (C32H40Cl2N6O3S2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C32H40Cl2N6O3S2 HCl |
| Molecular Weight | 728.19 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 2 |
Related Avatrombopag Standards
- Avatrombopag Impurity 31 (CAS 1126-09-6)
- Avatrombopag Impurity 52 (CAS 1224935-95-8)
- Avatrombopag Impurity 20 (CAS 123971-45-9)
- Avatrombopag Impurity 43 (CAS 1268118-96-2)
- Avatrombopag Impurity 5 (CAS 1290121-42-4)
- Avatrombopag Impurity 24 (CAS 1534575-19-3)
- Avatrombopag Impurity 92 (CAS 160114-74-9)
- Avatrombopag Impurity 37 (CAS 17766-28-8)
Recommended Standards
- Telmisartan Impurity 11 (CAS 884330-09-0)
- Salbutamol EP impurity N DiFormate (CAS CATO-C4X-117618)
- Oseltamivir Impurity 253 (CAS CATO-C4X-1720253)
- 3-Allyl-4-butoxy-5-methoxybenzaldehyde (CAS 128139-63-9)
- Methyl 3-oxopiperazine-2-carboxylate (CAS 41817-92-9)
- Pyribambenz-Propyl (CAS 420138-40-5)
- Methyl 6-(benzylamino)nicotinate (CAS 1355236-80-4)
- 5-Bromo-2-methyl-4-(piperidin-1-yl)pyridine (CAS 103971-18-2)
- 1-(3-(Piperidin-1-yl)phenyl)ethanone (CAS 39911-01-8)
- Semaglutide impurity 74 (CAS CATO-C4X-222674)
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